For me, one of the high points is the internal build up of the space station with new laboratory equipment.
There weren't any astronauts until I was about 10. Yuri Gagarin went into space right around my 10th birthday.
Since the Columbia accident, the Russian space agency, or the Russian space program, has been literally carrying the load bringing us all the supplies we need on the Progress vehicle, smaller amounts on the Soyuz vehicles.
In the 19th Century people were looking for the Northwest Passage. Ships were lost and brave people were killed, but that doesn't mean we never went back to that part of the world again, and I consider it the same in space exploration.
We're going to be focusing our science on things that will take us farther and longer into space. For many of those experiments, the crew members are human guinea pigs, which is fine; that's part of my job. I don't mind being a human guinea pig.
The Space Shuttle will stop directly below the Space Station and Sergei and I will be looking out two different windows looking straight down at the Space Shuttle.