Lewis H. Kuller (January 9, 1934 – October 25, 2022) was an American epidemiologist. (wikipedia)
That's part of the concern when you do these trials - women throwing in the sponge and eating anything they want. Unfortunately, a lot of women do that anyway.
As you begin to age and lose neurons, the ventricles get bigger.
A key question is whether this is all driven by our high dietary salt intake. One hypothesis is that high salt intake drives blood pressure throughout life, and early treatment and control of blood pressure may profoundly affect longevity and the quality of life.
You can write all the guidelines you want, but you're living in a society where food is our number one social behavior.
The last step would be to prove that substantially lowering blood pressure throughout life would prevent the increasing WGM and VG. The story is evolving rapidly now.
Waist circumference is far more important than simply measuring how much someone weighs.
These variables may have the strongest associations with longevity among older people.