Charles Scott Sherrington
Charles Scott Sherrington
Sir Charles Scott Sherrington OM GBE PRSwas an English neurophysiologist, histologist, bacteriologist, and a pathologist, Nobel laureate and president of the Royal Society in the early 1920s. He received the Nobel Prize in Physiology or Medicine with Edgar Adrian, 1st Baron Adrian, in 1932 for their work on the functions of neurons. Prior to the work of Sherrington and Adrian, it was widely accepted that reflexes occurred as isolated activity within a reflex arc. Sherrington received the prize for showing...
NationalityBritish
ProfessionScientist
Date of Birth27 November 1857
That a strong stimulus to such an afferent nerve, exciting most or all of its fibres, should in regard to a given muscle develop inhibition and excitation concurrently is not surprising.
Further study of central nervous action, however, finds central inhibition too extensive and ubiquitous to make it likely that it is confined solely to the taxis of antagonistic muscles.
The brain seems a thoroughfare for nerve-action passing its way to the motor animal. It has been remarked that Life's aim is an act not a thought. To-day the dictum must be modified to admit that, often, to refrain from an act is no less an act than to commit one, because inhibition is coequally with excitation a nervous activity.
A rainbow every morning who would pause to look at? The wonderful which comes often or is plentifully about us is soon taken for granted. Th at is practical enough. It allows us to get on with life. But it may stultify if it cannot on occasion be thrown off . To recapture now and then childhood’s wonder, is to secure a driving force for occasional grown-up thoughts.
The terminal path may, to distinguish it from internuncial common paths, be called the final common path. The motor nerve to a muscle is a collection of such final common paths.
With the nervous system intact the reactions of the various parts of that system, the 'simple reflexes', are ever combined into great unitary harmonies, actions which in their sequence one upon another constitute in their continuity what may be termed the 'behaviour'.
As followers of natural science we know nothing of any relation between thoughts and the brain, except as a gross correlation in time and space.
He solved at a stroke the great question of the direction of nerve-currents in their travel through brain and spinal cord.
If it is mind that we are searching the brain, then we are supposing the brain to be much more than a telephone-exchange. We are supposing it to be a telephone-exchange along with subscribers as well.
This integrative action in virtue of which the nervous system unifies from separate organs an animal possessing solidarity, an individual, is the problem before us.
If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.
That our being should consist of two fundamental elements [physical and psychical] offers I suppose no greater inherent improbability than that it should rest on one only.