Linus Pauling
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Linus Pauling
Linus Carl Pauling was an American chemist, biochemist, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. Pauling was one of the founders of the fields of quantum chemistry and molecular biology...
NationalityAmerican
ProfessionScientist
Date of Birth28 February 1901
CityPortland, OR
CountryUnited States of America
I believe that you can, by taking some simple and inexpensive measures, lead a longer life and extend your years of well-being. My most important recommendation is that you take vitamins every day in optimum amounts to supplement the vitamins that you receive in your food.
In teaching, you do not want to COVER things, you want to UNCOVER them. The best way to get good ideas is to have lots of ideas.
It was obvious-to me at any rate-that the answer was to why an enzyme is able to speed up a chemical reaction by as much as 10 million times. It had to do this by lowering the energy of activation-the energy of forming the activated complex. It could do this by forming strong bonds with the activated complex, but only weak bonds with the reactants or products.
An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
I believe that you can, by taking some simple and inexpensive measures, extend your life and your years of well-being. My most important recommendation is that you take vitamins every day in optimun amounts, to supplement the vitamins you receive in your food.
...It would be possible to make much more progress than has been made if the NCI knew its job better, knew how to make discoveries...The NCI really does not know how to make discoveries....So long as the NCI is not willing to follow up ideas that seem good to people who have had experience making discoveries, the work of the NCI is going to be pedestrian.
..The truly fraudulent claims must be discarded. But novel methods of therapy should not be rejected because they are novel, or because they run counter to some generally accepted belief ("which may just be biased"), or because we do not understand the mechanism of the proposed treatment, or because it has come from an unconventional source.
It has been recognized that hydrogen bonds restrain protein molecules to their native configurations, and I believe that as the methods of structural chemistry are further applied to physiological problems it will be found that the significance of the hydrogen bond for physiology is greater than that of any other single structural feature.
I think that the formation of [DNA's] structure by Watson and Crick may turn out to be the greatest developments in the field of molecular genetics in recent years.
We may say that life has borrowed from inanimate processes the same mechanism used in producing these striking structures that are crystals.
The McCarthy period came along...and many of the other scientists who had been working on these same lines gave up. Probably saying "Why should I sacrifice myself? I am a scientist, I am supposed to be working on scientific things, so I don't need to put myself at risk by talking about these possibilities." And I have said that perhaps I'm just stubborn... I have said "I don't like anybody to tell me what to do or to think, except Mrs. Pauling."
I recognize that many physicists are smarter than I am-most of them theoretical physicists. A lot of smart people have gone into theoretical physics, therefore the field is extremely competitive. I console myself with the thought that although they may be smarter and may be deeper thinkers than I am, I have broader interests than they have.
During the time that [Karl] Landsteiner gave me an education in the field of imununology, I discovered that he and I were thinking about the serologic problem in very different ways. He would ask, What do these experiments force us to believe about the nature of the world? I would ask, What is the most. simple and general picture of the world that we can formulate that is not ruled by these experiments? I realized that medical and biological investigators were not attacking their problems the same way that theoretical physicists do, the way I had been in the habit of doing.
We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine.