Smallpox, which spreads by respiration and kills roughly one in three of those infected, took hundreds of millions of lives during a recorded history dating to Pharaonic Egypt. The last case was in 1978, and the disease was declared eradicated on May 8, 1980.
There is no reliable way to calculate from the number of recorded compliance issues how many Americans have had their communications improperly collected, stored or distributed by the NSA.