Nikolaos Scarmeas Compensate Quotations

When more and more of the disease accumulates in the brain they are able to compensate for a long time, but at some point they cannot cope with it anymore and they manifest the disease.

They go downhill faster. We think it's because they have delayed the onset so long that a lot of the brain changes have accumulated and when they reach the point of clinical manifestation, they can't compensate any more and they sort of crash.