The monolithic nature of IIS which has been a total pain for people to build applications has been replaced, ... molded on the kind of modularity Apache is known for.
Windows has gone from being a laggard in management to a leader. System Center is at the center, and Windows is key, but the learning we share together as people that drives us forward.
What's needed now are software technologies that interconnect computing systems, people and data to produce more rapid answers to the questions of science, and to help researchers use computation in the most effective manner.